منابع مشابه
Heparan Sulfate Biosynthesis
Heparan sulfate is perhaps the most complex polysaccharide known from animals. The basic repeating disaccharide is extensively modified by sulfation and uronic acid epimerization. Despite this, the fine structure of heparan sulfate is remarkably consistent with a particular cell type. This suggests that the synthesis of heparan sulfate is tightly controlled. Although genomics has identified the...
متن کاملHeparan sulfate gets specific
lthough the cellular adhesion molecule CD44 is involved in processes ranging from lymphocyte homing to tumor metastasis, it has remained unclear how CD44 transduces the intracellular signals required for such a broad range of activities. On page 755, Okamoto et al. propose a surprising mechanism for CD44 signal transduction: a cytoplasmic domain is cleaved from the protein, after which it trans...
متن کاملHeparan sulfate proteoglycans
Studies of the involvement of ECM molecules in cell attachment, growth, and differentiation have revealed a central role of heparan sulfate (HS) proteoglycans (HSPGs) in early embryogenesis, morphogenesis, angiogenesis, and epithelial-mesenchymal interactions (1–3). HS chains bind a multitude of proteins and ensure that a wide variety of bioactive molecules (e.g., heparin-binding growth factors...
متن کاملHeparan sulfate proteoglycans.
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions. Here, we discuss changing views on the specificity of protein-heparan sulfate binding and the activity of HSPGs as receptors and core...
متن کاملHeparan sulfate: antithrombotic or not?
ance to peanuts. J. Clin. Invest. 111:1065–1072. doi:10.1172/JCI200316142. 7. Cohen, S.B., Webb, L.M., and Feldmann, M. 1996. The method of deriving human T-cell clones alters the proportion of IL-10-producing cells. Immunology. 87:343–347. 8. Demeure, C.E., et al. 1995. Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m507729200